State-of-the-art instrument enhances research in structural biology and protein analysis

ZÜRICH: $BRKR #BRKR--Bruker announces the acceptance of a 1.2 GHz Ascend™ Nuclear Magnetic Resonance (NMR) spectrometer at the Swiss High-field NMR Facility, operated jointly by the University of Basel, ETH Zürich, and the University of Zürich. This state-of-the-art instrument will significantly enhance the research capabilities of several user groups, enabling advanced studies in structural biology and macromolecular analysis. The instrument, located at the University of Zürich, is the second 1.2 GHz NMR in Switzerland, with the first at ETH used for developing solid-state NMR techniques, and studying materials and biological systems.

The Swiss High-field NMR Facility has locations at Biozentrum Basel and at University of Zürich. The new 1.2 GHz NMR complements the existing 800 MHz NMR in Basel and other high-field NMRs for protein structure determination, measurement of protein dynamics, ligand binding studies, conformational fingerprinting, and the analysis of protein-protein interactions.

Professor Oliver Zerbe from University of Zürich stated: "The 1.2 GHz NMR enables the study G protein-coupled receptors (GPCRs) in greater detail to define dynamic behavior and conduct drug binding studies. The higher resolution and dispersion at 1.2 GHz enhance the study of interactions of drug candidates with GPCRs. Professor Ricarda Törner, who will join UZH in 2025, will greatly benefit from increased resolution in her studies of intrinsically disordered proteins. Similarly, Professor Sigel's group anticipates significant advantages for their RNA research."

Stephan Grzesiek, Professor of Structural Biology at Biozentrum Basel, who started the initiative for a Swiss high-field solution NMR, remarked: “Finally, we also have a highest-field NMR available for Swiss solution NMR. It will enable new NMR methods and explore the limits of detection in disease-relevant applications, such as GPCR signaling and cancer.”

His colleague, Professor Sebastian Hiller from Biozentrum Basel noted: "The 1.2 GHz NMR allows to study structures and dynamics of chaperone-client complexes at atomic resolution. These detailed descriptions will reveal biophysical laws governing chaperone function, with implications for neurodegenerative diseases, such as Parkinson’s."

Detlef Günther, Professor for Trace Element and Micro Analysis, and Vice President of Research at ETH Zürich (2015-2022) when the instrument was ordered, remarked: "We are excited to provide our scientists with this ultra-high field NMR. This collaboration will enable groundbreaking research in structural biology, furthering our understanding of complex biological systems.”

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Fonte: Business Wire